Publications

Lab members | Equal contribution

Garushyants SK, Sane M, Selifanova MV, Agashe D, Bazykin GA and Gelfand MS. Mutational signatures in wild type Escherichia coli strains reveal dominance of DNA polymerase errors. Preprint

Prakash A, Agashe D and Khan I (In review). Disruption of flour beetle microbiota limits experimentally evolved immune priming response, but not pathogen resistance. Preprint

Hariharan N, Ghosh S, Nallan AN, Ramesh A, Agashe D and Palakodeti D (In review). ES30L: A large subunit rRNA expansion segment enriched in mammals and birds. Preprint

2023

Agashe D, Sane M and Singhal S (In press). Revisiting the role of genetic variation in adaptation. American Naturalist

Sane M, Diwan GD, Bhat BA, Wahl LM and Agashe D (2023). Shifts in mutation spectra enhance access to beneficial mutations. Proceedings of the National Academy of Science 120:e2207355120 | Preprint | Online access | NCBS news article

Raval PK, Ngan WY, Gallie J and Agashe D (2023). The layered costs and benefits of translational redundancy. eLife 12:e81005 Open Access | eLife Digest | Press release

Ravi Kumar V, Agavekar G and Agashe D (2023). Fitness landscapes reveal context-dependent benefits of oviposition behavior. Evolution 77(2):550–561 Open Access

Wortel M, Agashe D, …. and Pennings P [total 36 authors] (2023). Towards evolutionary predictions: current promises and challenges. Evolutionary Applications 16(1):3–21 Open Access

2022

Sanjenbam P, Shivaprasad PV and Agashe D (2022). Impact of phyllosphere Methylobacterium on host rice landraces. Microbiology Spectrum 10(4):e00810-22 Open access

Agashe D (2022). The evolutionary impacts of synonymous mutations. In: Sauna Z and Kimchi-Sarfaty C (eds). Single Nucleotide Polymorphisms. Springer, Cham. Preprint | Online Access

Wahl LM and Agashe D (2022). Selection bias in mutation accumulation. Evolution 76: 528-540 Online Access | NCBS news article

Agashe D, Maheshwary S,…, Roy Chaudhuri C, Devi P [total 13 authors] (2022). Career challenges for young independent researchers in India. Current Science 122:143 Online access

Prakash A, Agashe D and Khan I (2022). The costs and benefits of basal infection resistance vs immune priming responses in an insect. Developmental and Comparative Immunology 126:104261 Online access | Preprint

2021

Samhita L, Raval PK, Stephenson G, Thutupalli S and Agashe D (2021). The impact of mistranslation on phenotypic variability and fitness. Evolution 75(5):1201-1217 Open Access | NCBS News article | Biopatrika interview

Samhita L (2021). The Boggarts of biology: How non-genetic changes influence the genotype. Current Genetics 67: 65–77. Online Access

2020

Agarwal A and Agashe D (2020). The red flour beetle Tribolium castaneum: A model for host-microbiome interactions. PLoS One 15(10): e0239051 Open Access

Joshi S and Agashe D (2020). Ontogenic color change, survival, and mating in the damselfly Agriocnemis pygmaea Rambur (Insecta: Odonata). Ecological Entomology 45: 1015-1024 Online Access | NCBS news article | Research Matters article

Samhita L, Raval PK and Agashe D (2020). Global mistranslation increases cell survival under stress in E. coli. PLoS Genetics 16(3): e1008654 Open Access | NCBS news article | Faculty of 1000 recommendation

Sanjenbam P, Buddidathi R, Venkatesan R, Shivaprasad PV and Agashe D (2020). Phenotypic diversity of Methylobacterium associated with rice landraces in North-east India. PLoS One 15(2): e0228550 Open Access

2019

Phalnikar K, Kunte K and Agashe D (2019). Disrupting butterfly microbiomes does not affect host survival and development. Proceedings of the Royal Society of London B 286:20192438 Open Access | Featured in Quanta Magazine | NCBS news article

Deb R, Nair A and Agashe D (2019). Host dietary specialization and neutral assembly shape gut bacterial communities of wild dragonflies. PeerJ 7:e8058 Open Access | Featured in Quanta Magazine| NCBS news article

Khan I, Prakash A and Agashe D (2019). Pathogen susceptibility and fitness costs explain variation in immune priming across natural populations of flour beetles. Journal of Animal Ecology 88(9): 1332-1342 Online access | Preprint on bioRxiv

Kaminski Strauss S, …, Agashe D, …, Walunjkar N, …. and Yitzak Pilpel [total 63 authors] (2019). Evolthon: A community endeavor to evolve lab evolution. PLoS Biology 17(3): e3000182 Open access

Agavekar G, Agashe D and Economo EP (2019). Dimensions of ant diversity on a small tropical island. Insect conservation and diversity 12: 161-171. Online access

2018

Ravi Kumar V, Issar S and Agashe D (2018). The induction of larval resource preference in heterogeneous habitats. Ecological Entomology 43, 719–730 Online access

Sane M, Miranda JJ and Agashe D (2018). Antagonistic pleiotropy for carbon use is rare in new mutations. Evolution 72(10):2202-2213 Open access | NCBS News article

Diwan GD and Agashe D (2018). Wobbling forth and drifting back: The evolutionary history and impact of tRNA modifying enzymes. Molecular Biology and Evolution 35(8):2046-2059 Open access | NCBS News article

Phalnikar K, Kunte K and Agashe D (2018). Dietary and developmental shifts in butterfly-associated bacterial communities. Royal Society Open Science 5:171559 Open access

Agashe D and Kunte K (editors) (2018). Special issue on the Genetics of Adaptation. Molecular Biology and Evolution Virtual Issue

Khan I, Prakash A, Issar S, Umarani M, Sasidharan R, Masagalli JN, Lama P, Venkatesan R and Agashe D (2018). Female chemical warfare drives fitness effects of group sex ratio. American Naturalist 191(3):306–317 Preprint on bioRxiv | Journal access

Mahajan S and Agashe D (2018). Translational selection for speed is not sufficient to explain variation in bacterial codon usage bias. Genome Biology and Evolution 10(2):562–576 Open access | GBE Special issue on synonymous mutations

Agarwal A and Agashe D. Restoring ancestral microbiome aids beetle adaptation to new diets. Preprint

2017

Khan I, Prakash A, and Agashe D (2017). Experimental evolution of insect immune memory vs. pathogen resistance. Proceedings of the Royal Society of London B 284:20171583 Published online Dec 2017 | News coverage | NCBS News article

Agashe D (2017). The road not taken: Could stress-specific mutations lead to different evolutionary paths? PLoS Biology 15(6): e2002862 Open access

Khan I, Agashe D and Rolff J (2017). Early life inflammation, immune response and aging. Proceedings of the Royal Society of London B 284:20170125 Journal access | Correction | Faculty of 1000 recommendation

2016

Diwan GD and Agashe D (2016). The frequency of internal Shine-Dalgarno – like motifs in prokaryotes. Genome Biology and Evolution 8(6):1722-1733 Open access

Khan I, Prakash A and Agashe D (2016). Divergent immune priming responses across life stages and populations of flour beetles. Ecology and Evolution 6: 7847–7855 Open access

Agashe D, Sane M, Phalnikar K, Diwan GD, Habibullah A, Martinez-Gomez NC, Sahasrabuddhe V, Polachek W, Wang J, Chubiz L and Marx CJ (2016). Large-effect beneficial synonymous mutations mediate rapid and parallel adaptation in a bacterium. Molecular Biology and Evolution 33: 1542-1553. Open access | MBE News

Nair A and Agashe D (2016). Host-specific, spatial and temporal variation in culturable gut bacterial communities of dragonflies. Current Science 110(8): 1513-1523. PDF | SI | Cover | Highlighted in “In this issue”

Khan I, Prakash A and Agashe D (2016). Immunosenescence and the ability to survive bacterial infection in the red flour beetle Tribolium castaneum. Journal of Animal Ecology 85: 291-301. PDF | SI

Nayak DD, Agashe D, Lee M-C and Marx CJ (2016). Selection maintains apparently degenerate metabolic pathways due to tradeoffs in using methylamine for carbon versus nitrogen. Current Biology 26:1416-1426 PDF

2015

Kunte K and Agashe D [guest editors] (2015). Special section on Evolutionary Biology, in Current Science 108:1835-1873. PDF of the preface

Carroll SM, Chubiz LM, Agashe D and Marx CJ (2015). Parallel and divergent evolutionary solutions for the optimization of an engineered central metabolism in Methylobacterium extorquens AM1. Microorganisms 3:152-174 PDF

2014

Parent CE, Agashe D and Bolnick DI (2014). Intraspecific competition reduces niche width in experimental populations. Ecology and Evolution 4(20): 3878-3990 Open access

Agashe D and Shankar N (2014). The evolution of bacterial DNA base composition. Journal of Experimental Zoology, series B 322 (7): 517-528 PDF

2009–2013

Agashe D, Martinez-Gomez NC, Drummond DA and Marx CJ (2013). Good codons, bad transcript: large reductions in gene expression and fitness arising from synonymous mutations in a key enzyme. Molecular Biology and Evolution 30(3): 549-560 PDF | SI | Faculty of 1000 recommendation

Falk JJ, Parent CE, Agashe D and Bolnick DI (2012). Drift and selection entwined: Asymmetric reproductive isolation in an experimental niche shift. Evolutionary Ecology Research 14: 403-423 PDF

Agashe D and Bolnick DI (2012). Dietary niche and population dynamic feedbacks in a novel habitat. Oikos 121(3): 347-356 PDF

Agashe D, Falk JJ and Bolnick DI (2011). Effects of founding genetic variation on adaptation to a novel resource. Evolution 65(9): 2481-2491 PDF | SI

Agashe D and Bolnick DI (2010). Intraspecific genetic variation and competition interact to facilitate niche expansion. Proceedings of the Royal Society of London, series B 277(1696): 2915-2924 PDF | SI

Tiple A, Agashe D, Khurad AM and Kunte K (2009). Population dynamics and seasonal polyphenism of Chilades pandava (Lepidoptera: Lycaenidae) in central India. Current Science 97(12): 1774-1779 PDF

Agashe D (2009). The stabilizing effect of intraspecific genetic variation on population dynamics in novel and ancestral habitats. American Naturalist 174(2): 255-267 PDF | SI | Faculty of 1000 recommendation | American Society of Naturalists’ Student Paper Award