Bacterial evolution

See all publications from the lab

Lab members | Equal contribution


Sane M, Diwan GD, Bhat BA, Wahl LM and Agashe D (2023). Shifts in mutation spectra enhance access to beneficial mutations. Proceedings of the National Academy of Science 120:e2207355120 | Preprint | Online access | NCBS news article

Raval PK, Ngan WY, Gallie J and Agashe D (2023). The layered costs and benefits of translational redundancy. eLife 12:e81005 Open Access | eLife Digest | Press release


Mahajan S and Agashe D (2022). Evolutionary jumps in bacterial GC content. G3|Genes|Genomes|Genetics 12:jkac108. Preprint | Online access | Research Matters article

Wahl LM and Agashe D (2022). Selection bias in mutation accumulation. Evolution 76: 528-540 Online Access | NCBS news article


Samhita L, Raval PK, Stephenson G, Thutupalli S and Agashe D (2021). The impact of mistranslation on phenotypic variability and fitness. Evolution 75(5):1201-1217 Open Access | NCBS News article | Biopatrika interview


Samhita L, Raval PK and Agashe D (2020). Global mistranslation increases cell survival under stress in E. coliPLoS Genetics 16(3): e1008654 Open Access | NCBS news article | Recommended by Faculty of 1000

Sanjenbam P, Buddidathi R, Venkatesan R, Shivaprasad PV and Agashe D (2020). Phenotypic diversity of Methylobacterium associated with rice landraces in North-east India. PLoS One 15(2): e0228550 Open Access


Kaminski Strauss S, …, Agashe D, …, Walunjkar N, …. and Yitzak Pilpel [total 63 authors] (2019). Evolthon: A community endeavor to evolve lab evolution. PLoS Biology 17(3): e3000182 Open access


Sane M, Miranda JJ and Agashe D (2018). Antagonistic pleiotropy for carbon use is rare in new mutations. Evolution 72(10):2202-2213 Open access | NCBS News article

Diwan GD and Agashe D (2018). Wobbling forth and drifting back: The evolutionary history and impact of tRNA modifying enzymes. Molecular Biology and Evolution 35(8):2046-2059 Open access | NCBS News article

Mahajan S and Agashe D (2018). Translational selection for speed is not sufficient to explain variation in bacterial codon usage bias. Genome Biology and Evolution 10(2):562–576 Open access | GBE Special issue on synonymous mutations


Agashe D (2017). The road not taken: Could stress-specific mutations lead to different evolutionary paths? PLoS Biology 15(6): e2002862 Open access


Diwan GD and Agashe D (2016). The frequency of internal Shine-Dalgarno – like motifs in prokaryotes. Genome Biology and Evolution 8(6):1722-1733 Open access

Agashe D, Sane M, Phalnikar K, Diwan GD, Habibullah A, Martinez-Gomez NC, Sahasrabuddhe V, Polachek W, Wang J, Chubiz L and Marx CJ (2016). Large-effect beneficial synonymous mutations mediate rapid and parallel adaptation in a bacterium. Molecular Biology and Evolution 33: 1542-1553. Open access | MBE News

Nayak DD, Agashe D, Lee M-C and Marx CJ (2016). Selection maintains apparently degenerate metabolic pathways due to tradeoffs in using methylamine for carbon versus nitrogen. Current Biology 26:1416-1426 PDF


Carroll SM, Chubiz LM, Agashe D and Marx CJ (2015). Parallel and divergent evolutionary solutions for the optimization of an engineered central metabolism in Methylobacterium extorquens AM1. Microorganisms 3:152-174 PDF


Agashe D and Shankar N (2014). The evolution of bacterial DNA base composition. Journal of Experimental Zoology, series B 322 (7): 517-528 PDF


Agashe D, Martinez-Gomez NC, Drummond DA and Marx CJ (2013). Good codons, bad transcript: large reductions in gene expression and fitness arising from synonymous mutations in a key enzyme. Molecular Biology and Evolution 30(3): 549-560 PDF | SI | Recommended by Faculty of 1000

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