Tag: genome evolution

Mutational signatures in wild E coli

Bacterial genomes experience lots of mutations that result from a complex mix of DNA damage, errors made by DNA polymerase, and errors repaired or made by repair enzymes. Do these processes leave a tell-tale signature in the genome, and can we use it to infer which processes were most important? A new paper in Genome... Continue Reading →

New paper: Pinning big jumps in genome GC

Bacteria have remarkably diverse base composition in their genomes, with many well studied cases of rapid GC reduction associated with obligate symbiosis and genome streamlining in poor environments. But we don't really understand how GC content generally changes in evolutionary time. To find out, Saurabh tested different evolutionary models of change in GC content in... Continue Reading →

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