Mutations are central for evolution, and recent work has suggested that the type of mutations sampled by organisms may be important for evolution. Earlier work from our lab and that of Lindi Wahl suggested that flipping a long-term mutational bias should be generally beneficial, by allowing populations to sample unexplored mutational space. We have now... Continue Reading →
We are looking to recruit a Postdoctoral Fellow with a start date of February or March 2025. The position is for a minimum of 2 years (extendable for up to 4 years), supported by an ongoing grant from the DBT/Wellcome Trust India Alliance to study the evolutionary effects of mutation bias. Salary and benefits will... Continue Reading →
Bacterial genomes experience lots of mutations that result from a complex mix of DNA damage, errors made by DNA polymerase, and errors repaired or made by repair enzymes. Do these processes leave a tell-tale signature in the genome, and can we use it to infer which processes were most important? A new paper in Genome... Continue Reading →
Our paper describing the evolutionary effects of shifts in mutation bias is now published! We started out by asking if mutation spectrum could alter the fitness effects of new mutations in E. coli. To our surprise, we found a consistent effect across many environments, but could not attribute the difference to any particular properties of... Continue Reading →
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