Tag: mutation spectrum

Mutational signatures in wild E coli

Bacterial genomes experience lots of mutations that result from a complex mix of DNA damage, errors made by DNA polymerase, and errors repaired or made by repair enzymes. Do these processes leave a tell-tale signature in the genome, and can we use it to infer which processes were most important? A new paper in Genome... Continue Reading →

New paper: Mutation bias shifts can be adaptive

Our paper describing the evolutionary effects of shifts in mutation bias is now published! We started out by asking if mutation spectrum could alter the fitness effects of new mutations in E. coli. To our surprise, we found a consistent effect across many environments, but could not attribute the difference to any particular properties of... Continue Reading →

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