Our long-dreamt-of project on understanding the effects of widely varying tRNA gene copy number is finally complete! In a new paper, we describe the growth consequences of altering redundancy in the bacterial translation machinery. We find that the costs and benefits of redundancy vary with the possible growth rate, i.e. it is nutrient-driven. This was... Continue Reading →
New paper: Mistranslation can be good!
Our work on ‘useful’ mistakes in bacteria (E. coli) is finally out! Laasya and Parth found that making rebel proteins not encoded by our DNA can be a good thing. In cells that frequently make mistakes, the accumulated ‘junk’ proteins end up triggering a high alert situation. This allows the cells to better deal with... Continue Reading →