In the second installment of our series of reviews on the lab's favourite papers, Shubha Govindarajan writes about a classic paper that gave a new perspective on individual variation and tradeoffs. Read on! Fig 1 from van Noordwijk & de Jong 1986, American Naturalist Acquisition and Allocation of Resources: Their Influence on Variation in Life... Continue Reading →
Our paper reporting the impact of selection bias in mutation accumulation (MA) experiments is now published! A few years ago, Mrudula had tested the effect of single mutations accumulated in MA experiments (see Sane et al 2018, Evolution), finding that a surprisingly large fraction were beneficial. In the new paper, mathematician Lindi Wahl uses simulations... Continue Reading →
The Indian National Young Academy of Science (INYAS) conducted a survey of ~800 young scientists establishing an independent research career in India. The report and associated recommendations will hopefully guide positive change. Read the full report here.
Arun's paper reporting the detailed costs and benefits of evolved immune priming is now published! In an exciting earlier study, we had found that flour beetles exposed to the pathogen Bacillus thuringiensis adapted rapidly via the evolution of either immune priming or pathogen resistance. The new work – led by Arun (now at Edinburgh University)... Continue Reading →
Read Laasya's short interview about her work and career goals, and our paper on the phenotypic effects of mistranslation.
Our collaborative work (with Shashi Thutupalli’s lab at NCBS) on tracking mistranslation-induced phenotypic variability is now published! Protein sequences often differ because of underlying differences in DNA sequence (i.e. genetic mutations). However, making mistakes while building the protein can also introduce differences in the protein sequence, although at a low frequency. Proteins altered in this... Continue Reading →
Laasya’s single-author review on how non-genetic changes can contribute to evolution is now out in Current Genetics! Transfer of information in biology usually occurs from nucleic acids to protein, but not vice-versa (The Central Dogma). Any molecular alteration that does not change the DNA sequence (genotype) is generally short lived, and is thought to have... Continue Reading →