New paper: Selection biases results of mutation accumulation experiments

Our paper reporting the impact of selection bias in mutation accumulation (MA) experiments is now published! A few years ago, Mrudula had tested the effect of single mutations accumulated in MA experiments (see Sane et al 2018, Evolution), finding that a surprisingly large fraction were beneficial. In the new paper, mathematician Lindi Wahl uses simulations to show that this high incidence of beneficial vacations mutations is at least partly explained by the action of natural selection during colony growth between single-cell bottlenecks. Importantly, we devised a simple correction factor to allow for a more accurate estimation of the distribution of fitness affects. For a nice intuitive summary of the work, check out this NCBS news article by Nivedita Mukherjee.

Comments are closed.

Website Powered by WordPress.com.

Up ↑